PhytoScience - Science 
HIV - Invitro
Active constituents against HIV-1 protease from Garcinia mangostana.
Chen SX, Wan M, Loh BN.
The ethanol extract of Garcinia mangostana L. (Guttiferae) showed potent inhibitory activity against HIV-1 protease.
The activity-guided purification of the extract resulted in the isolation of two active, known compounds.
The chemical structures of the isolated compounds were established by spectroscopic analyses as mangostin (IC50 = 5.12 +/- 0.41 microM) and gamma-mangostin (IC50 = 4.81 +/- 0.32 microM).
The type of inhibition by both compounds is noncompetitive.
PMID: 8792678 [PubMed - indexed for MEDLINE]